When Barack Obama took the oath of office in January 2009, the country faced problems unlike any the country had faced in generations. The economic system was near collapse. Each year, food-borne illnesses sickened millions, workplace hazards killed and injured thousands on the job, and air pollution triggered asthma attacks in millions of children and adults. Long procedural delays and political interference in the regulatory process caused deficits in safety and health standards, exacerbating these problems. This report examines efforts to address such delays and interference by focusing on the regulatory process, including transparency and participation, regulatory analysis, scientific integrity, and the role of the White House, especially the Office of Information and Regulatory Affairs (OIRA) within the Office of Management and Budget (OMB), in shaping the administration's record. This is the third of three OMB Watch reports evaluating the Obama administration’s record on regulatory issues.